Estimation of gene frequency and test for Hardy-Weinberg equilibrium in the HLA system.
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Estimation of gene frequency and test for Hardy-Weinberg equilibrium in the HLA system.
This paper concerns the testing for Hardy-Weinberg equilibrium and the estimation of gene frequency in the human leukocyte antigens (HLA) system. An extensive simulation study for both testing and estimation is given for investigating the performance of the projection method by Eguchi and Matsuura, which has a closed form, and the method is asymptotically equivalent to the maximum likelihood me...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1990
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.9087149